Showing posts with label Science. Show all posts
Showing posts with label Science. Show all posts

Thursday, January 30, 2020

Week 3 Story: The Faucet vs. the Milli-Q

Once upon a time, in a research lab far, far away, a Scientist was conducting a very important experiment. At one point, the unthinkable happened and the Scientist accidentally poured a whole bottle of sulfuric acid into his reaction! They needed to save the reaction, and fast! If left uncorrected, the reaction, and maybe even the experiment, would be ruined forever. They consulted the heavenly Primary Investigator for guidance, and she suggest to dilute the solution using water from the Faucet.


So, They prayed for 0.271 teraseconds (Ts) to the Faucet to dispense some of this lifesaving water. Finally, the Faucet answered in the guise of a small vapor cloud that said, "You need my help, sure, but can you withstand the full force and raw quality of my water? Surely, you know that I should not be put into your reaction, the water I give is much too impure and would taint your reaction."
The Scientist looked crestfallen. They lowered their head thinking that there was no hope for their experiment, but the Faucet offered some wisdom.
"Go forth and pray to the Milli-Q, the device that can bear the force of my water and transform it miraculously into the purest water imaginable."

The Milli-Q in all its glory : Fisher Scientific

And so the Scientist prayed and prayed to the Milli-Q, and, after 0.008314 Ts, the Milli-Q responded thus: "Let the Faucet come down," the Milli-Q decreed. "I will help you. I will see to it that no drop of that water is wasted or allowed to trouble any experiment."
And so for 6.626 gigaseconds (Gs), the Scientist made the necessary preparations to connect the Milli-Q to the Faucet. They assembled tubes and gears, sinks and drains, and all manner of equipment. At the end of the Scientist's preparation, the Faucet, who was bringing water from the farthest reaches of the plumbing system, began the outpour with a roaring deluge of impure water. However, the Milli-Q, true to its word, was in place and received the impact and the deluge vanished within its chambers. For a while, the Faucet kept flooding more and more water into the Milli-Q, yet nothing came out the other end. The Scientist waited with bated breath, and worried that all their prayers had amounted to nothing. When, suddenly, the Milli-Q let out a small, calm stream of water that looked clearer than any water the Scientist had ever seen.
"Thats what a 22-micron filter can do for you," the Milli-Q said, grinning from tube to tube.
"It's beautiful," the Scientist whispered. "It's so pure."
Thus, the Scientist saved the experiment just in time to discover the answer to the question that no one cared  no, a hot dog is not a sandwich.

Author's Notes:
Whew! Second story in the books. This story is based on the Ganges River origin story where Bhagiratha is seeking salvation for his ancestors who died without receiving the proper funeral rights. At this time, there was no Ganges River, and even no oceans. He prays for many years to Brahma, who directs him to seek the help of both Shiva and Ganga (the goddess of the Ganges) to direct water down to the earth. After praying for tens of thousands of years each to both gods, and living an ascetic life subsisting off of practically nothing, Bhagiratha finally witnesses Ganga release the flood onto the earth and Shiva absorbs the force, releasing just a small stream that eventually becomes the Ganges. Bhagiratha saved his relatives, and India now has the holy Ganges River because of it.
To help understand my story, one Ts is equal to about 32,000 years, and one Gs is equal to about 32 years. A Primary Investigator is the title for the professor that is in charge of entire research topic, usually a senior tenure professor who has associate professors, grad students, and undergrads working under her. A Milli-Q, in short, is a device that purifies water to such an extent that it is practically only H2O with no other chemicals in it. In my lab, we use a Milli-Q to remove even microscopic DNA from the water.
I really enjoyed the original story, and maybe because of that, I am not very happy with my story. It's ok but not great. Maybe I needed better characters than just a couple inanimate objects.... anyway I think next story I will try something else besides the science-children's story mix that I've done for the last two.

Bibliography:
Narayan, R. K. "The Ramayana"

Tuesday, January 21, 2020

Week 2 Story: The Little Cancer that Could (SAD)

Once upon a time, in a body that works just like yours, there were a group of cells happily living and growing and dividing all together.
"How nice our lives are," the cells bubbled together. "We just follow our programming and we even get told when to die! Oh, speaking of when to die, hey apoptotic signal! We were just talking about you!"
"Hello, cells," the apoptotic signal greeted them. "It is my job to tell you when it is time to make room for new cells! You all have very important jobs, but it's also important for the survival of the whole body that you make room for new cells."
On the edge of the group of cells, a carcinoma cell thought to itself, "I don't want to die! I want to grow and divide faster than I do now! When the others are going to be killed, I am going to escape and continue to grow and divide because I shouldn't have to die if I don't want to."

So, when the time came for all the cells to undergo apoptosis and make room for new cells, the carcinoma cell executed its plan and escaped its death.
"Now I can divide as much as I want," the carcinoma cell exclaimed. And the carcinoma cell duplicated itself many, many, many times, until there were so many of the carcinoma cell, that the apoptotic signal noticed them. Knowing that the carcinoma cell was too strong to kill without any help, the apoptotic signal went to the T cell and begged for its help.


But, the carcinoma had seen the apoptotic signal go to the T cell, and knew that it was too strong for the apoptotic signal to kill it alone. So the carcinoma cell watched the T cell go to work, so that the carcinoma cell could outsmart it.
As the carcinoma cell secretly watched, the T cell came upon a nervous cell, and looked at a very small part of the cell's shell. The cell was shaking as the T cell latched onto the cell and exclaimed, "You're sick!"
Then, in quick succession, the T cell released a few chemicals to go and kill the sick cell. In only a moments,  the sick cell was a dead cell.
The carcinoma cell quickly realized that it was only after the T cell reviewed a part of the sick cell's shell that the T cell knew to kill the cell. "If I can make myself look like a normal cell," the carcinoma cell thought, "then maybe I can trick the T cell into letting me go!"
As quick as it could, the carcinoma cell changed the format of every single copy of itself so that all had the same part as a normal cell. When the T cell finally found the carcinoma cell with the apoptotic signal close behind, the T cell looked at that specific part. The T cell looked very closely over the carcinoma cell, but, after a while, decided that it was close enough to normal and that there was nothing that it could do.
"Looks fine to me," said the T cell.
"B-... Bu-... But that can't be! I know that it's not meant to be there," the apoptotic signal stuttered. "The carcinoma cell will ruin the whole body!"
But the carcinoma cell had gone right back to dividing rapidly, not listening at all to the apoptotic signal. It grew and grew and grew and grew, until no other cells had any room for them to grow! But still the carcinoma cell kept growing. Until finally, the carcinoma cell was so big that no other cells could even move around it. Now, the carcinoma cell wasn't just hurting other cells; it was hurting the body. The body became sicker and sicker until it couldn't support itself anymore.
The carcinoma cell, in its own selfish desires, ultimately brought its own downfall.

-----
Author's Note: Phew! First story done! I wanted to play around with the story about the Monkey Who Gathered Lotus, because I like how both of the main character's worked to outsmart and defeat the other. I also wanted to incorporate my science background into this story and explain a tough concept (the immune system response to cancerous cells) in an easy-to-comprehend way! I really enjoyed the fun contrasting dynamic between a children's book style of writing with the scientific labels for the molecules that were my characters. I had to change the story around though, making the Bodhisatta's equivalent character (the carcinoma cell) into the 'bad guy' and the Devadatta's character (the apoptotic signal) into the 'good guy.' This also changed the lesson of the story from "Work hard and be good" to "Don't be too selfish," but I think it worked. I also had to oversimplify slightly for the story such as combining the two types of T cells into one character. (Normally, a helper T cell notices the cancer and a cytotoxic T cell kills the cell.) Overall, I am happy with this first story and I know that I will get better as the semester progresses!
Vaga-Buon Voyage!

Images:
Figure 1: Cartoon drawing of a normal cell next to a carcinoma cell with description of the carcinoma cell in green: YouTube
Figure 2: Cartoon drawing of a Helper T Cell: Growing and Developing Healthy Relationships

Bibliography:
Chalmers, Robert. "The Monkey Who Gathered Lotuses" Tayodhamma Jataka, Jataka Volume 1. https://sacred-texts.com/bud/j1/j1061.htm